Biochem/physiol Actions

Fibroblast growth factor receptor 4 (FGFR4) protein possesses tyrosine-protein kinase activity and serves as a cell-surface receptor for fibroblast growth factors. It regulates cell proliferation, differentiation, and migration. FGFR4 also participates in survival during embryonic development. It helps with tissue homeostasis, tissue repair, angiogenesis, and inflammation in adults. FGFR4 is expressed at a high level in various cancer types. It plays a key role in tumor subtype differentiation in luminal breast cancer and metastatic disease. Oncogenic mutations of the FGFR4 gene are associated with rhabdomyosarcoma (RMS) and primary gastric cancer.

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General description

Fibroblast growth factor receptor 4 (FGFR4) protein is a tyrosine kinase (TK) receptor comprising an extracellular domain, a transmembrane domain, and an intracellular domain. FGFR4 is expressed in the adrenal cortex, bile duct, cervix, cornea, heart, hepatocyte, intestine, kidney, liver, lung, lymph node, mammary gland, muscle, ovary, pituitary gland, renal tubular epithelium, retina, skin, spleen, stomach, ureter, urothelium, and uterus. FGFR4 gene is located on human chromosome 5q35.2.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity

The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.